On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones

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Authors
Sutherell, Charlotte L
  Ley, Steven Victor
Publication Date
2016-08-24
Journal Title
Synthesis
ISSN
0039-7881
Publisher
Georg Thieme
Volume
49
Pages
135-144
Language
English
Type
Article
This Version
AM
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Citation
Sutherell, C. L., & Ley, S. V. (2016). On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones. Synthesis, 49 135-144. https://doi.org/10.1055/s-0035-1562792
Abstract
An improved, scalable synthetic route to the quinazolinone natural product 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one is reported. The applicability of this method to analogue synthesis and the synthesis of related natural products is explored. Finally, reactivity of the scaffold to a variety of electrophilic reagents, generating products stereoselectively, is reported.
Keywords
quinazolinone, alkaloid, 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one, deoxyvasicinone
Relationships
Is supplemented by: https://doi.org/10.17863/CAM.523
Sponsorship
Charlotte Sutherell was funded by the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine. We gratefully acknowledge the EPSRC (SVL, Grant Nos. EP/K099494/1 and EP/K039520/1).
Funder references
EPSRC (EP/K009494/1)
Identifiers
External DOI: https://doi.org/10.1055/s-0035-1562792
This record's URL: https://www.repository.cam.ac.uk/handle/1810/257339

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