From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition.
Published version
Peer-reviewed
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Repository DOI
Change log
Authors
Young, Adam MH
Chakrabarti, Bhismadev
Roberts, David
Lai, Meng-Chuan
Suckling, John https://orcid.org/0000-0002-5098-1527
Abstract
Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed.
Description
Keywords
Autism, Brain, Inflammation, NF-κB, Amniotic Fluid, Animals, Antigens, Surface, Autism Spectrum Disorder, Autoantibodies, Body Fluids, Brain, Brain Chemistry, Chemokines, Cytokines, Female, Glutamic Acid, HLA Antigens, Haplorhini, Humans, Immunity, Maternally-Acquired, Inflammation, Inflammation Mediators, Lipopolysaccharides, Maternal-Fetal Exchange, Mice, Nerve Tissue Proteins, Neuroglia, Neuroimaging, Pregnancy, Pregnancy Complications, Infectious, Prenatal Exposure Delayed Effects, Signal Transduction
Journal Title
Mol Autism
Conference Name
Journal ISSN
2040-2392
2040-2392
2040-2392
Volume Title
7
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Medical Research Council (G0600977)
Medical Research Council, Autism Research Trust, William Binks Autism Neuroscience Fellowship