Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits
Ingram, James N
Nature Publishing Group
MetadataShow full item record
Wolpe, N., Ingram, J. N., Tsvetanov, K., Geerligs, L., Kievit, R., Henson, R., Wolpert, D., et al. (2016). Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature Communications https://doi.org/10.17863/CAM.4398
The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation – a reduction in the perceived intensity of sensations from self-generated compared to external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience). Importantly, attenuation increases with age, in proportion to reduced sensory sensitivity. This effect is associated with differences in the structure and functional connectivity of the pre-supplementary motor area (pre-SMA), assessed with magnetic resonance imaging. The results suggest that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits. This shift may contribute to the motor and cognitive changes observed with age.
Cam-CAN research was supported by the Biotechnology and Biological Sciences Research Council (BB/H008217/1). JBR and NW were supported by the James S. McDonnell Foundation 21st Century Science Initiative, Scholar Award in Understanding Human Cognition. JBR was also supported by Wellcome Trust  and the Medical Research Council [MC-A060-5PQ30]. DMW was supported by the Wellcome Trust , Human Frontier Science Program and the Royal Society Noreen Murray Professorship in Neurobiology. RNH was supported by the Medical Research Council [MC-A060-5PR10]. RAK was supported by a Sir Henry Wellcome Trust Postdoctoral Fellowship . LG was funded by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO).
WELLCOME TRUST (103838/Z/14/Z)
Wellcome Trust (unknown)
Wellcome Trust (097803/Z/11/Z)
Wellcome Trust (093875/Z/10/Z)
Medical Research Council (MC_UP_1401/1)
Medical Research Council (MC_U105579226)
This record's URL: https://www.repository.cam.ac.uk/handle/1810/260170
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/