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dc.contributor.authorZouggari, Yasmineen
dc.contributor.authorAit-Oufella, Hafiden
dc.contributor.authorBonnin, Philippeen
dc.contributor.authorSimon, Tabassomeen
dc.contributor.authorSage, Andrew Pen
dc.contributor.authorGuérin, Coralieen
dc.contributor.authorVilar, Joséen
dc.contributor.authorCaligiuri, Giuseppinaen
dc.contributor.authorTsiantoulas, Dimitriosen
dc.contributor.authorLaurans, Ludivineen
dc.contributor.authorDumeau, Edouarden
dc.contributor.authorKotti, Salmaen
dc.contributor.authorBruneval, Patricken
dc.contributor.authorCharo, Israel Fen
dc.contributor.authorBinder, Christoph Jen
dc.contributor.authorDanchin, Nicolasen
dc.contributor.authorTedgui, Alainen
dc.contributor.authorTedder, Thomas Fen
dc.contributor.authorSilvestre, Jean-Sébastienen
dc.contributor.authorMallat, Ziaden
dc.date.accessioned2016-09-23T08:41:25Z
dc.date.available2016-09-23T08:41:25Z
dc.date.issued2013-09-15en
dc.identifier.issn1078-8956
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260338
dc.description.abstractAcute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that following acute MI in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6Chi monocyte mobilization and recruitment, leading to enhanced tissue injury and deterioration of myocardial function. Genetic (Baff-r deficiency) or antibody-mediated (CD20- or Baff-specific antibody) depletion of mature B lymphocytes impedes Ccl7 production and monocyte mobilization, limits myocardial injury and improves heart function. These effects are recapitulated in mice with B cell selective Ccl7 deficiency. We also show that elevated circulating levels of Ccl7 and Baff in patients with acute MI predict increased risk of death or recurrent MI at follow-up. The work unravels a previously unsuspected interaction between mature B lymphocytes and monocytes following acute ischemia, and identifies novel therapeutic targets for this devastating condition.
dc.description.sponsorshipThis work was supported by Inserm, British Heart Foundation (Z.M.), European Research Council (Z.M.), Fondation Coeur et Recherche (Z.M., T.S., N.D.), Fondation pour la Recherche Medicale (J.S.S.), European Union Seven Framework programme TOLERAGE (Z.M.), Fondation Leducq transatlantic network (C.J.B., D.T., A.T., J.S.S., Z.M.), National Institutes of Health grants AI56363 and AI057157, and a grant from The Lymphoma Research Foundation (T.F.T).
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleB lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarctionen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Nature Publishing Group at http://dx.doi.org/10.1038/nm.3284.en
prism.endingPage1280
prism.publicationDate2013en
prism.publicationNameNature Medicineen
prism.startingPage1273
prism.volume19en
dc.identifier.doi10.17863/CAM.4569
dcterms.dateAccepted2013-06-26en
rioxxterms.versionofrecord10.1038/nm.3284en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013-09-15en
dc.contributor.orcidMallat, Ziad [0000-0003-0443-7878]
dc.identifier.eissn1546-170X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (PG/11/107/29236)


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