Show simple item record

dc.contributor.authorMendichovszky, Iosifen
dc.contributor.authorPriest, ANen
dc.contributor.authorBowden, DJen
dc.contributor.authorHunter, Sen
dc.contributor.authorJoubert, Ien
dc.contributor.authorHilborne, Sen
dc.contributor.authorGraves, Martinen
dc.contributor.authorBaglin, Ten
dc.contributor.authorLomas, Daviden
dc.date.accessioned2016-09-29T14:40:48Z
dc.date.available2016-09-29T14:40:48Z
dc.date.issued2016-08-30en
dc.identifier.issn0938-7994
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260454
dc.description.abstract$\textit{Objectives}$ Lower limb deep venous thrombosis (DVT) is a common condition with high morbidity and mortality. The aim of the study was to investigate the temporal evolution of the acute thrombus by magnetic resonance imaging (MRI) and its relationship to venous recanalization in patients with recurrent DVTs. $\textit{Methods}$ Thirteen patients with newly diagnosed lower limb DVTs underwent MRI with non-contrast MR venography (NC-MRV) and MR direct thrombus imaging (MR-DTI), an inversion-recovery water-selective fast gradient-echo acquisition. Imaging was performed within 7 days of the acute thrombotic event, then at 3 and 6 months. $\textit{Results}$ By 3 months from the thrombotic event a third of the thrombi had resolved and by 6 months about half of the cases had resolved on the basis of vein recanalisation using NC-MRV. On the initial MR-DTI acute thrombus was clearly depicted by hyperintense signal, while the remaining thrombi were predominantly low signal at 3 and 6 months. Some residual thrombi contained small and fragmented persisting hyperintense areas at 3 months, clearing almost completely by 6 months. $\textit{Conclusions}$ Our study suggests that synergistic venous assessment with combined NC-MRV and MR-DTI is able to distinguish acute venous thrombosis from the established (old) or evolving DVT detected by ultrasound.
dc.description.sponsorshipNational Institute for Health Research, Addenbrooke’s Charitable Trust
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmagnetic resonance imagingen
dc.subjectvenous thrombosisen
dc.subjectdiagnosisen
dc.subjectlongitudinal studyen
dc.subjectclinical decision-makingen
dc.titleCombined MR direct thrombus imaging and non-contrast magnetic resonance venography reveal the evolution of deep vein thrombosis: a feasibility studyen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00330-016-4555-4en
prism.publicationDate2016en
prism.publicationNameEuropean Radiologyen
dc.identifier.doi10.17863/CAM.4689
dcterms.dateAccepted2016-08-09en
rioxxterms.versionofrecord10.1007/s00330-016-4555-4en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-08-30en
dc.contributor.orcidMendichovszky, Iosif [0000-0002-3777-2827]
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.contributor.orcidLomas, David [0000-0003-2904-8617]
dc.identifier.eissn1432-1084
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:57:20 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International