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dc.contributor.authorSharma, Rahulen
dc.contributor.authorXia, Xiaojuanen
dc.contributor.authorCano, Liliana Men
dc.contributor.authorEvangelisti, Edouarden
dc.contributor.authorKemen, Ericen
dc.contributor.authorJudelson, Howarden
dc.contributor.authorOome, Stanen
dc.contributor.authorSambles, Christineen
dc.contributor.authorvan, den Hoogen DJen
dc.contributor.authorKitner, Miloslaven
dc.contributor.authorKlein, Joëlen
dc.contributor.authorMeijer, Harold JGen
dc.contributor.authorSpring, Otmaren
dc.contributor.authorWin, Joeen
dc.contributor.authorZipper, Reinharden
dc.contributor.authorBode, Helge Ben
dc.contributor.authorGovers, Francineen
dc.contributor.authorKamoun, Sophienen
dc.contributor.authorSchornack, Sebastianen
dc.contributor.authorStudholme, David Jen
dc.contributor.authorVan, den Ackerveken Guidoen
dc.contributor.authorThines, Marcoen
dc.date.accessioned2016-09-29T15:05:32Z
dc.date.available2016-09-29T15:05:32Z
dc.date.issued2015-10-05en
dc.identifier.citationBMC Genomics. 2015 Oct 05;16(1):741
dc.identifier.issn1471-2164
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260486
dc.description.abstractAbstract Background Downy mildews are the most speciose group of oomycetes and affect crops of great economic importance. So far, there is only a single deeply-sequenced downy mildew genome available, from Hyaloperonospora arabidopsidis. Further genomic resources for downy mildews are required to study their evolution, including pathogenicity effector proteins, such as RxLR effectors. Plasmopara halstedii is a devastating pathogen of sunflower and a potential pathosystem model to study downy mildews, as several Avr-genes and R-genes have been predicted and unlike Arabidopsis downy mildew, large quantities of almost contamination-free material can be obtained easily. Results Here a high-quality draft genome of Plasmopara halstedii is reported and analysed with respect to various aspects, including genome organisation, secondary metabolism, effector proteins and comparative genomics with other sequenced oomycetes. Interestingly, the present analyses revealed further variation of the RxLR motif, suggesting an important role of the conservation of the dEER-motif. Orthology analyses revealed the conservation of 28 RxLR-like core effectors among Phytophthora species. Only six putative RxLR-like effectors were shared by the two sequenced downy mildews, highlighting the fast and largely independent evolution of two of the three major downy mildew lineages. This is seemingly supported by phylogenomic results, in which downy mildews did not appear to be monophyletic. Conclusions The genome resource will be useful for developing markers for monitoring the pathogen population and might provide the basis for new approaches to fight Phytophthora and downy mildew pathogens by targeting core pathogenicity effectors.
dc.titleGenome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthoraen
dc.typeArticle
dc.date.updated2016-09-29T15:05:31Z
dc.language.rfc3066en
dc.rights.holderSharma et al.
prism.publicationDate2015en
dc.identifier.doi10.17863/CAM.4720
dcterms.dateAccepted2015-08-27en
rioxxterms.versionofrecord10.1186/s12864-015-1904-7en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-05en
dc.contributor.orcidSchornack, Sebastian [0000-0002-7836-5881]
dc.identifier.eissn1471-2164
rioxxterms.typeJournal Article/Reviewen


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