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dc.contributor.authorMarioni, Riccardo Een
dc.contributor.authorProust-Lima, Cecileen
dc.contributor.authorAmieva, Heleneen
dc.contributor.authorBrayne, Carolen
dc.contributor.authorMatthews, Fionaen
dc.contributor.authorDartigues, Jean-Francoisen
dc.contributor.authorJacqmin-Gadda, Heleneen
dc.date.accessioned2016-09-29T15:06:28Z
dc.date.available2016-09-29T15:06:28Z
dc.date.issued2015-10-24en
dc.identifier.citationBMC Public Health. 2015 Oct 24;15(1):1089
dc.identifier.issn1471-2458
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260506
dc.description.abstractAbstract Background Identifying modifiable lifestyle correlates of cognitive decline and risk of dementia is complex, particularly as few population-based longitudinal studies jointly model these interlinked processes. Recent methodological developments allow us to examine statistically defined sub-populations with separate cognitive trajectories and dementia risks. Methods Engagement in social, physical, or intellectual pursuits, social network size, self-perception of feeling well understood, and degree of satisfaction with social relationships were assessed in 2854 participants from the Paquid cohort (mean baseline age 77 years) and related to incident dementia and cognitive change over 20-years of follow-up. Multivariate repeated cognitive information was exploited by defining the global cognitive functioning as the latent common factor underlying the tests. In addition, three latent homogeneous sub-populations of cognitive change and dementia were identified and contrasted according to social environment variables. Results In the whole population, we found associations between increased engagement in social, physical, or intellectual pursuits and increased cognitive ability (but not decline) and decreased risk of incident dementia, and between feeling understood and slower cognitive decline. There was evidence for three sub-populations of cognitive aging: fast, medium, and no cognitive decline. The social-environment measures at baseline did not help explain the heterogeneity of cognitive decline and incident dementia diagnosis between these sub-populations. Conclusions We observed a complex series of relationships between social-environment variables and cognitive decline and dementia. In the whole population, factors such as increased engagement in social, physical, or intellectual pursuits were related to a decreased risk of dementia. However, in a sub-population analysis, the social-environment variables were not linked to the heterogeneous patterns of cognitive decline and dementia risk that defined the sub-groups.
dc.titleSocial activity, cognitive decline and dementia risk: a 20-year prospective cohort studyen
dc.typeArticle
dc.date.updated2016-09-29T15:06:27Z
dc.language.rfc3066en
dc.rights.holderMarioni et al.
prism.publicationDate2015en
dc.identifier.doi10.17863/CAM.4740
dcterms.dateAccepted2015-10-16en
rioxxterms.versionofrecord10.1186/s12889-015-2426-6en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-24en
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.contributor.orcidMatthews, Fiona [0000-0002-1728-2388]
dc.identifier.eissn1471-2458
rioxxterms.typeJournal Article/Reviewen


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