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dc.contributor.authorOtten, Jen
dc.contributor.authorStomby, Aen
dc.contributor.authorWaling, Men
dc.contributor.authorIsaksson, Aen
dc.contributor.authorTellström, Aen
dc.contributor.authorLundin-Olsson, Len
dc.contributor.authorBrage, Sorenen
dc.contributor.authorRyberg, Men
dc.contributor.authorSvensson, Men
dc.contributor.authorOlsson, Ten
dc.date.accessioned2016-10-05T12:26:08Z
dc.date.available2016-10-05T12:26:08Z
dc.date.issued2016-06-30en
dc.identifier.issn1520-7552
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260648
dc.description.abstractBACKGROUND: Means to reduce future risk for cardiovascular disease in subjects with type 2 diabetes are urgently needed. METHODS: Thirty-two patients with type 2 diabetes (age 59 ± 8 years) followed a Paleolithic diet for 12 weeks. Participants were randomized to either standard care exercise recommendations (PD) or 1-h supervised exercise sessions (aerobic exercise and resistance training) three times per week (PD-EX). RESULTS: For the within group analyses, fat mass decreased by 5.7 kg (IQR: -6.6, -4.1; $p$ < 0.001) in the PD group and by 6.7 kg (-8.2, -5.3; $p$ < 0.001) in the PD-EX group. Insulin sensitivity (HOMA-IR) improved by 45% in the PD ($p$ < 0.001) and PD-EX ($p$ < 0.001) groups. HbA1c decreased by 0.9% (-1.2, -0.6; $p$ < 0.001) in the PD group and 1.1% (-1.7, -0.7; $p$ < 0.01) in the PD-EX group. Leptin decreased by 62% ($p$ < 0.001) in the PD group and 42% ($p$ < 0.001) in the PD-EX group. Maximum oxygen uptake increased by 0.2 L/min (0.0, 0.3) in the PD-EX group, and remained unchanged in the PD group ($p$ < 0.01 for the difference between intervention groups). Male participants decreased lean mass by 2.6 kg (-3.6, -1.3) in the PD group and by 1.2 kg (-1.3, 1.0) in the PD-EX group ($p$ < 0.05 for the difference between intervention groups). CONCLUSIONS: A Paleolithic diet improves fat mass and metabolic balance including insulin sensitivity, glycemic control, and leptin in subjects with type 2 diabetes. Supervised exercise training may not enhance the effects on these outcomes, but preserves lean mass in men and increases cardiovascular fitness. Copyright © 2016 John Wiley & Sons, Ltd.
dc.description.sponsorshipSwedish Heart and Lung Foundation (Grant ID: 20120450), King Gustav V and Queen Victoria’s Foundation, The Swedish Diabetes Research Foundation (Grant ID: 2014-096), County Council of Västerbotten (Grant ID: VLL-460481), Umeå University Sweden
dc.languageENGen
dc.language.isoenen
dc.publisherWiley
dc.subjectPaleolithic dieten
dc.subjectdiet interventionen
dc.subjectexerciseen
dc.subjectglycosylated haemoglobin Aen
dc.subjectinsulin sensitivityen
dc.subjectleptinen
dc.subjecttype 2 diabetesen
dc.titleBenefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes.en
dc.typeArticle
prism.publicationDate2016en
prism.publicationNameDiabetes Metab Res Reven
dc.identifier.doi10.17863/CAM.4880
dcterms.dateAccepted2016-05-10en
rioxxterms.versionofrecord10.1002/dmrr.2828en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-06-30en
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn1520-7560
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/3)
cam.issuedOnline2016-05-27en
rioxxterms.freetoread.startdate2017-05-27


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