Transition states and cell fate decisions in epigenetic landscapes.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Moris, Naomi https://orcid.org/0000-0003-1910-5454
Correia Antunes Pina, Cristina Pina https://orcid.org/0000-0002-2575-6301
Arias, Alfonso Martinez
Abstract
Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the relationship between gene activity and cell fates during development. Over the past few years, it has become a useful framework for interpreting results from single-cell transcriptomics experiments. It has led to the proposal that, during fate transitions, cells experience smooth, continuous progressions of global transcriptional activity, which can be captured by (pseudo)temporal dynamics. Here, focusing strictly on the fate decision events, we suggest an alternative view: that fate transitions occur in a discontinuous, stochastic manner whereby signals modulate the probability of the transition events.
Description
Keywords
Animals, Cell Differentiation, Cell Lineage, Computational Biology, Epigenesis, Genetic, Humans, Models, Genetic, Stochastic Processes
Journal Title
Nat Rev Genet
Conference Name
Journal ISSN
1471-0056
1471-0064
1471-0064
Volume Title
17
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Kay Kendall Leukaemia Fund (KKL888)
Kay Kendall Leukaemia Fund