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Screening and prevention of stillbirth.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Smith, Gordon CS 

Abstract

Stillbirth is delivery of a baby at or after 24 weeks of gestational age (UK definition) not showing any signs of life. It affects almost one in 200 pregnancies and is the single major cause of perinatal death. Stillbirth is associated with a wide range of maternal demographic characteristics, but most of the variations in stillbirth risk are independent of these characteristics. Stillbirth is the end point of multiple processes, but the single most common cause is probably placental dysfunction. Stillbirth is associated with a wide range of biochemical and ultrasonic predictors, but there is limited evidence to support population-based screening. However, the evidence based is weak due to the use of poorly characterised screening tests, the failure to couple risk assessment with a clearly effective intervention for those who screen positive and inadequate study sample sizes. Basic research needs to identify better predictors, and clinical trials need to adopt more rigorous methodologies.

Description

Keywords

biomarkers, intervention, screening, stillbirth, ultrasound, ABO Blood-Group System, Abortion, Spontaneous, Black People, Cesarean Section, Delivery, Obstetric, Diabetes Mellitus, Female, Humans, Infant, Newborn, Labor, Induced, Maternal Age, Obesity, Parity, Perinatal Death, Pregnancy, Pregnancy Complications, Pregnancy, Multiple, Pregnancy-Associated Plasma Protein-A, Prenatal Diagnosis, Risk Assessment, Risk Factors, Stillbirth, Substance-Related Disorders, Tobacco Smoke Pollution, Ultrasonography, Prenatal, alpha-Fetoproteins

Journal Title

Best Pract Res Clin Obstet Gynaecol

Conference Name

Journal ISSN

1521-6934
1532-1932

Volume Title

Publisher

Elsevier BV