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Micro-connectomics: probing the organization of neuronal networks at the cellular scale.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Schröter, Manuel 
Bullmore, Edward T 

Abstract

Defining the organizational principles of neuronal networks at the cellular scale, or micro-connectomics, is a key challenge of modern neuroscience. In this Review, we focus on graph theoretical parameters of micro-connectome topology, often informed by economical principles that conceptually originated with Ramón y Cajal's conservation laws. First, we summarize results from studies in intact small organisms and in samples from larger nervous systems. We then evaluate the evidence for an economical trade-off between biological cost and functional value in the organization of neuronal networks. Various results suggest that many aspects of neuronal network organization are indeed the outcome of competition between these two fundamental selection pressures.

Description

Keywords

Animals, Brain, Connectome, Humans, Models, Neurological, Neural Pathways, Neurons, Neurosciences

Journal Title

Nat Rev Neurosci

Conference Name

Journal ISSN

1471-003X
1471-0048

Volume Title

18

Publisher

Springer Science and Business Media LLC
Sponsorship
This work was supported by the National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre.