Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project.
View / Open Files
Authors
InterAct Consortium,
Romaguera, D
Guevara, M
Norat, T
Sharp, S
Slimani, N
Schulze, MB
Buijsse, B
Buckland, G
Molina-Montes, E
Sánchez, MJ
Moreno-Iribas, MC
Bendinelli, B
Grioni, S
van der Schouw, YT
Arriola, L
Beulens, JW
Boeing, H
Clavel-Chapelon, F
Cottet, V
Crowe, FL
de Lauzon-Guillan, B
Franks, PW
Gonzalez, C
Hallmans, G
Kaaks, R
Key, TJ
Nilsson, P
Overvad, K
Palla, L
Palli, D
Panico, S
Quirós, JR
Rolandsson, O
Romieu, I
Sacerdote, C
Spijkerman, AMW
Teucher, B
Tjonneland, A
Tormo, MJ
Tumino, R
van der, ADL
Feskens, EJM
Riboli, E
Publication Date
2011-09Journal Title
Diabetes Care
ISSN
0149-5992
Publisher
American Diabetes Association
Volume
34
Issue
9
Pages
1913-1918
Language
ENG
Type
Article
Metadata
Show full item recordCitation
InterAct Consortium,, Romaguera, D., Guevara, M., Norat, T., Langenberg, C., Forouhi, N., Sharp, S., et al. (2011). Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project.. Diabetes Care, 34 (9), 1913-1918. https://doi.org/10.2337/dc11-0891
Abstract
OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort study including 11,994 incident type 2 diabetic case subjects and a stratified subcohort of 15,798 participants selected from a total cohort of 340,234 participants with 3.99 million person-years of follow-up, from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The relative Mediterranean diet score (rMED) (score range 0-18) was used to assess adherence to MDP on the basis of reported consumption of nine dietary components characteristic of the Mediterranean diet. Cox proportional hazards regression, modified for the case-cohort design, was used to estimate the association between rMED and risk of type 2 diabetes, adjusting for confounders. RESULTS: The multiple adjusted hazard ratios of type 2 diabetes among individuals with medium (rMED 7-10 points) and high adherence to MDP (rMED 11-18 points) were 0.93 (95% CI 0.86-1.01) and 0.88 (0.79-0.97), respectively, compared with individuals with low adherence to MDP (0-6 points) (P for trend 0.013). The association between rMED and type 2 diabetes was attenuated in people <50 years of age, in obese participants, and when the alcohol, meat, and olive oil components were excluded from the score. CONCLUSIONS: In this large prospective study, adherence to the MDP, as defined by rMED, was associated with a small reduction in the risk of developing type 2 diabetes in this European population.
Keywords
Anthropometry, Diabetes Mellitus, Type 2, Diet, Mediterranean, Female, Humans, Life Style, Male, Middle Aged, Prospective Studies, Socioeconomic Factors
Sponsorship
MRC (MC_UU_12015/1)
Identifiers
External DOI: https://doi.org/10.2337/dc11-0891
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261094
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International