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Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

Published version
Peer-reviewed

Change log

Authors

Fitzpatrick, DE 
Ley, SV 

Abstract

Synthesis chemistry need not be limited to either only batch or only flow; rather, in the future we expect that it will consist of an amalgamation of the best and most appropriate methods. We have therefore devised a single reactor platform to conduct both batch and flow reactions, either singly or in concert, using open source technologies to automate, control and monitor individual processes. We illustrate this concept with the multistep synthesis of 5-methyl-4-propylthiophene-2-carboxylic acid to showcase the utility of this approach in a telescoped manner. Automated downstream processing techniques, consisting of continuous extraction and solvent switching steps, were also included, further freeing the chemist from routine laboratory tasks.

Description

Keywords

40 Engineering, 3405 Organic Chemistry, 34 Chemical Sciences, Bioengineering

Journal Title

Reaction Chemistry & Engineering

Conference Name

Journal ISSN

2058-9883
2058-9883

Volume Title

1

Publisher

Royal Society of Chemistry
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Woolf Fisher Trust, Engineering and Physical Sciences Research Council (Grant IDs: EP/K009494/1, EP/M004120/1 and EP/K039520/1)