Short-term changes in arterial inflammation predict long-term changes in atherosclerosis progression.
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Authors
Joseph, Philip
Ishai, Amorina
Mani, Venkatesh
Kallend, David
Fayad, Zahi A
Tawakol, Ahmed
Publication Date
2017-01Journal Title
European journal of nuclear medicine and molecular imaging
ISSN
1619-7070
Publisher
Springer
Volume
44
Pages
141-150
Language
English
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Joseph, P., Ishai, A., Mani, V., Kallend, D., Rudd, J., Fayad, Z. A., & Tawakol, A. (2017). Short-term changes in arterial inflammation predict long-term changes in atherosclerosis progression.. European journal of nuclear medicine and molecular imaging, 44 141-150. https://doi.org/10.1007/s00259-016-3524-0
Abstract
$\textit{Purpose}$: It remains unclear whether changes in arterial wall inflammation are associated with subsequent changes in the rate of structural progression of atherosclerosis. $\textit{Methods}$: In this sub-study of the dal-PLAQUE clinical trial, multi-modal imaging was performed using 18-fludeoxyglucose (FDG) positron emission tomography (PET, at 0 and 6 months) and magnetic resonance imaging (MRI, at 0 and 24 months). The primary objective was to determine whether increasing FDG uptake at 6 months predicted atherosclerosis progression on MRI at 2 years. Arterial inflammation was measured by the carotid FDG target-to-background ratio (TBR), and atherosclerotic plaque progression was defined as the percentage change in carotid mean wall area (MWA) and mean wall thickness (MWT) on MRI between baseline and 24 months. $\textit{Results}$: A total of 42 participants were included in this sub-study. The mean age of the population was 62.5 years, and 12 (28.6 %) were women. In participants with (vs. without) any increase in arterial inflammation over 6 months, the long-term changes in both MWT (% change MWT: 17.49 % vs. 1.74 %, $p$ = 0.038) and MWA (% change MWA: 25.50 % vs. 3.59 %, $p$ = 0.027) were significantly greater. Results remained significant after adjusting for clinical and biochemical covariates. Individuals with no increase in arterial inflammation over 6 months had no significant structural progression of atherosclerosis over 24 months as measured by MWT ($p$ = 0.616) or MWA ($p$ = 0.373). $\textit{Conclusions}$: Short-term changes in arterial inflammation are associated with long-term structural atherosclerosis progression. These data support the concept that therapies that reduce arterial inflammation may attenuate or halt progression of atherosclerosis.
Keywords
Carotid Arteries, Humans, Carotid Artery Diseases, Arteritis, Disease Progression, Fluorodeoxyglucose F18, Radiopharmaceuticals, Magnetic Resonance Imaging, Prognosis, Sensitivity and Specificity, Longitudinal Studies, Reproducibility of Results, Middle Aged, Female, Male, Positron Emission Tomography Computed Tomography
Sponsorship
F. Hoffmann-La Roche Ltd, McMaster University (Early Career Investigator award), National Institute for Health Research Cambridge Biomedical Research Centre, British Heart Foundation, Wellcome Trust
Funder references
British Heart Foundation (PG/09/083/27667)
British Heart Foundation (FS/12/29/29463)
Identifiers
External DOI: https://doi.org/10.1007/s00259-016-3524-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261422
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