Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve their affinity at DNA ends. These include DNA-PK
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1083-351X
Volume Title
Publisher
Publisher DOI
Sponsorship
Cancer Research Uk (None)
Cancer Research UK (18796)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (093167/Z/10/Z)