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Continuous subcutaneous insulin infusion therapy and multiple daily insulin injections in type 1 diabetes mellitus: a comparative overview and future horizons.

Accepted version
Peer-reviewed

Type

Article

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Authors

Mohd-Thabit, HA 

Abstract

INTRODUCTION: Continuous subcutaneous insulin infusion (CSII) therapy is currently accepted as a treatment strategy for type 1 diabetes. Transition from multiple daily injection therapy (MDI; including basal-bolus regimens) to CSII is based on expectations of better metabolic control and fewer hypoglycaemic events. Evidence to date has not been always conclusive. AREAS COVERED: Evidence for CSII and MDI in terms of glycaemic control, hypoglycaemia and psychosocial outcomes is reviewed in the adult and paediatric population with type 1 diabetes. Findings from studies on threshold-based insulin pump suspension and predictive low glucose management (PLGM) are outlined. Limitations of current CSII application and future technological developments are discussed. EXPERT OPINION: Glycaemic control and quality of life (QOL) may be improved by CSII compared to MDI depending on baseline HbA1c and hypoglycaemia rates. Future studies are expected to provide evidence on clinical and cost effectiveness in those who will benefit the most. Training, structured education and support are important to benefit from CSII. Novel technological approaches linking continuous glucose monitoring (CGM) and CSII may help mitigate against frequent hypoglycaemia in those at risk. Development of glucose-responsive automated closed-loop insulin delivery systems may reduce the burden of disease management and improve outcomes in type 1 diabetes.

Description

Keywords

Continuous subcutaneous insulin infusion, insulin pump, multiple daily injections, type 1 diabetes, Adult, Blood Glucose, Child, Diabetes Mellitus, Type 1, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Quality of Life

Journal Title

Expert Opinion on Drug Delivery

Conference Name

Journal ISSN

1742-5247
1744-7593

Volume Title

13

Publisher

Taylor & Francis
Sponsorship
Wellcome Trust (100574/Z/12/Z)
Support for the research work by JDRF, Seventh Framework Programme of the European Union, Diabetes UK, National Institute for Health Research Cambridge Biomedical Research Centre.