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dc.contributor.authorMurphy, IGen
dc.contributor.authorGraves, Martinen
dc.contributor.authorReid, Sen
dc.contributor.authorPatterson, Andrewen
dc.contributor.authorPatterson, Ien
dc.contributor.authorPriest, ANen
dc.contributor.authorLomas, Daviden
dc.date.accessioned2016-12-13T09:54:56Z
dc.date.available2016-12-13T09:54:56Z
dc.date.issued2017-04-01en
dc.identifier.issn0730-725X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261536
dc.description.abstract$\textit{Purpose:}$ Hepatic magnetic resonance elastography (MRE) is currently a breath-hold imaging technique. Patients with chronic liver disease can have comorbidities that limit their ability to breath-hold (BH) for the required acquisition time. Our aim was to evaluate whether stiffness measurements obtained from a navigator-triggered MRE acquisition are comparable to standard expiratory breath-hold, inspiratory breath-hold or free-breathing in healthy participants. $\textit{Materials and methods:}$ Twelve healthy participants were imaged using the four methods on a clinical 1.5 T MR system equipped with a product MRE system. Mean liver stiffness, and measurable area of stiffness (with a confidence threshold >95%) were compared between sequences using the concordance correlation coefficient. Repeatability of each sequence between two acquisitions was also assessed. $\textit{Results:}$ The standard BH expiratory technique had high concordance with the navigated technique (r = 0.716), and low concordance with the BH inspiration (r = 0.165) and free-breathing (r = 0.105) techniques. The navigator-triggered technique showed no statistical difference in measurable area of liver or in repeatability compared with the standard expiratory acquisition (p = 0.997 and p = 0.407 respectively). The free-breathing technique produced less measurable liver area and was less repeatable than the alternative techniques. The increase in acquisition time for navigator techniques was 3 min 6 s compared to standard expiratory breath-hold. $\textit{Conclusion:}$ Navigator-based hepatic MRE measurements are comparable to the reference standard expiratory breath-hold acquisition in healthy participants.
dc.description.sponsorshipThis work was supported by the Addenbrooke's Charitable Trust and the NIHR Comprehensive Biomedical Research Centre award to Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge.
dc.languageENGen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectelastographyen
dc.subjectfree-breathingen
dc.subjectliver stiffnessen
dc.subjectmagnetic resonanceen
dc.subjectnavigator- triggereden
dc.titleComparison of breath-hold, respiratory navigated and free-breathing MR elastography of the liveren
dc.typeArticle
prism.endingPage50
prism.publicationDate2017en
prism.publicationNameMagnetic Resonance Imagingen
prism.startingPage46
prism.volume37en
dc.identifier.doi10.17863/CAM.6734
dcterms.dateAccepted2016-10-05en
rioxxterms.versionofrecord10.1016/j.mri.2016.10.011en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-04-01en
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.contributor.orcidLomas, David [0000-0003-2904-8617]
dc.identifier.eissn1873-5894
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-10-13en
rioxxterms.freetoread.startdate2017-10-13


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International