Show simple item record

dc.contributor.authorO'Connor, James PBen
dc.contributor.authorAboagye, Eric Oen
dc.contributor.authorAdams, Judith Een
dc.contributor.authorAerts, Hugo JWLen
dc.contributor.authorBarrington, Sally Fen
dc.contributor.authorBeer, Ambros Jen
dc.contributor.authorBoellaard, Ronalden
dc.contributor.authorBohndiek, Sarahen
dc.contributor.authorBrady, Michaelen
dc.contributor.authorBrown, Ginaen
dc.contributor.authorBuckley, David Len
dc.contributor.authorChenevert, Thomas Len
dc.contributor.authorClarke, Laurence Pen
dc.contributor.authorCollette, Sandraen
dc.contributor.authorCook, Gary Jen
dc.contributor.authordeSouza, Nandita Men
dc.contributor.authorDickson, John Cen
dc.contributor.authorDive, Carolineen
dc.contributor.authorEvelhoch, Jeffrey Len
dc.contributor.authorFaivre-Finn, Corinneen
dc.contributor.authorGallagher, Ferdiaen
dc.contributor.authorGilbert, Fionaen
dc.contributor.authorGillies, Robert Jen
dc.contributor.authorGoh, Vickyen
dc.contributor.authorGriffiths, Johnen
dc.contributor.authorGroves, Ashley Men
dc.contributor.authorHalligan, Steveen
dc.contributor.authorHarris, Adrian Len
dc.contributor.authorHawkes, David Jen
dc.contributor.authorHoekstra, Otto Sen
dc.contributor.authorHuang, Erich Pen
dc.contributor.authorHutton, Brian Fen
dc.contributor.authorJackson, Edward Fen
dc.contributor.authorJayson, Gordon Cen
dc.contributor.authorJones, Andrewen
dc.contributor.authorKoh, Dow-Muen
dc.contributor.authorLacombe, Denisen
dc.contributor.authorLambin, Philippeen
dc.contributor.authorLassau, Nathalieen
dc.contributor.authorLeach, Martin Oen
dc.contributor.authorLee, Ting-Yimen
dc.contributor.authorLeen, Edward Len
dc.contributor.authorLewis, Jason Sen
dc.contributor.authorLiu, Yanen
dc.contributor.authorLythgoe, Mark Fen
dc.contributor.authorManoharan, Prakashen
dc.contributor.authorMaxwell, Ross Jen
dc.contributor.authorMiles, Kenneth Aen
dc.contributor.authorMorgan, Brunoen
dc.contributor.authorMorris, Stephenen
dc.contributor.authorNg, Tonyen
dc.contributor.authorPadhani, Anwar Ren
dc.contributor.authorParker, Geoff JMen
dc.contributor.authorPartridge, Mikeen
dc.contributor.authorPathak, Arvind Pen
dc.contributor.authorPeet, Andrew Cen
dc.contributor.authorPunwani, Shoniten
dc.contributor.authorReynolds, Andrew Ren
dc.contributor.authorRobinson, Simon Pen
dc.contributor.authorShankar, Lalitha Ken
dc.contributor.authorSharma, Ricky Aen
dc.contributor.authorSoloviev, Dmitryen
dc.contributor.authorStroobants, Sigriden
dc.contributor.authorSullivan, Daniel Cen
dc.contributor.authorTaylor, Stuart Aen
dc.contributor.authorTofts, Paul Sen
dc.contributor.authorTozer, Gillian Men
dc.contributor.authorvan, Herk Marcelen
dc.contributor.authorWalker-Samuel, Simonen
dc.contributor.authorWason, Jamesen
dc.contributor.authorWilliams, Kaye Jen
dc.contributor.authorWorkman, Paulen
dc.contributor.authorYankeelov, Thomas Een
dc.contributor.authorBrindle, Kevinen
dc.contributor.authorMcShane, Lisa Men
dc.contributor.authorJackson, Alanen
dc.contributor.authorWaterton, John Cen
dc.date.accessioned2016-12-14T15:00:17Z
dc.date.available2016-12-14T15:00:17Z
dc.date.issued2017-03en
dc.identifier.issn1759-4774
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261571
dc.description.abstractImaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored 'roadmap'. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use.
dc.description.sponsorshipDevelopment of this roadmap received support from Cancer Research UK and the Engineering and Physical Sciences Research Council (grant references A/15267, A/16463, A/16464, A/16465, A/16466 and A/18097), the EORTC Cancer Research Fund, and the Innovative Medicines Initiative Joint Undertaking (grant agreement number 115151), resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies' in kind contribution.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectHumansen
dc.subjectNeoplasmsen
dc.subjectOrganotechnetium Compoundsen
dc.subjectFolic Aciden
dc.subjectFluorodeoxyglucose F18en
dc.subjectRadiopharmaceuticalsen
dc.subjectPositron-Emission Tomographyen
dc.subjectPrognosisen
dc.subjectReproducibility of Resultsen
dc.subjectSelection Biasen
dc.subjectResearch Designen
dc.subjectCost-Benefit Analysisen
dc.subjectBiomarkers, Tumoren
dc.subjectClinical Decision-Makingen
dc.titleImaging biomarker roadmap for cancer studies.en
dc.typeArticle
prism.endingPage186
prism.publicationDate2017en
prism.publicationNameNature reviews. Clinical oncologyen
prism.startingPage169
prism.volume14en
dc.identifier.doi10.17863/CAM.6769
dcterms.dateAccepted2016-10-01en
rioxxterms.versionofrecord10.1038/nrclinonc.2016.162en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-03en
dc.contributor.orcidBohndiek, Sarah [0000-0003-0371-8635]
dc.contributor.orcidGallagher, Ferdia [0000-0003-4784-5230]
dc.contributor.orcidGilbert, Fiona [0000-0002-0124-9962]
dc.contributor.orcidGriffiths, John [0000-0001-7369-6836]
dc.contributor.orcidMorris, Stephen [0000-0002-5828-3563]
dc.contributor.orcidWason, James [0000-0002-4691-126X]
dc.contributor.orcidBrindle, Kevin [0000-0003-3883-6287]
dc.identifier.eissn1759-4782
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0515-10067)
pubs.funder-project-idCancer Research UK (16465)
pubs.funder-project-idCancer Research UK (16628)
pubs.funder-project-idMRC (G0300648)


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International