Repository logo
 

Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Published version
Peer-reviewed

Change log

Authors

Lodge, Katharine M 
Thompson, AA Roger 
Chilvers, Edwin R 
Condliffe, Alison M 

Abstract

Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.

Description

Keywords

Hypoxia, Neutrophil, Staphylococcus aureus, Animals, Disease Models, Animal, Humans, Hypoxia, Immunity, Innate, Neutrophils, Staphylococcal Infections, Staphylococcus aureus

Journal Title

Microbes Infect

Conference Name

Journal ISSN

1286-4579
1769-714X

Volume Title

19

Publisher

Elsevier BV
Sponsorship
This work was supported by a Wellcome Trust Research Training Fellowship awarded to K.M.L, Papworth Hospital Research and Development Department and the NIHR Cambridge Biomedical Research Centre.