Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Lodge, Katharine M
Thompson, AA Roger
Chilvers, Edwin R
Condliffe, Alison M
Abstract
Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.
Description
Keywords
Hypoxia, Neutrophil, Staphylococcus aureus, Animals, Disease Models, Animal, Humans, Hypoxia, Immunity, Innate, Neutrophils, Staphylococcal Infections, Staphylococcus aureus
Journal Title
Microbes Infect
Conference Name
Journal ISSN
1286-4579
1769-714X
1769-714X
Volume Title
19
Publisher
Elsevier BV
Publisher DOI
Sponsorship
This work was supported by a Wellcome Trust Research Training Fellowship awarded to K.M.L, Papworth Hospital Research and Development Department and the NIHR Cambridge Biomedical Research Centre.