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dc.contributor.authorMacKay, Jamesen
dc.contributor.authorMurray, PJen
dc.contributor.authorKasmai, Ben
dc.contributor.authorJohnson, Gen
dc.contributor.authorDonell, STen
dc.contributor.authorToms, APen
dc.date.accessioned2016-12-23T13:40:58Z
dc.date.available2016-12-23T13:40:58Z
dc.date.issued2017-05en
dc.identifier.issn1063-4584
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261712
dc.description.abstractObjective Magnetic resonance imaging (MRI) texture analysis is a method of analyzing subchondral bone alterations in osteoarthritis (OA). The objective of this study was to to evaluate the association between MR texture analysis and ground-truth subchondral bone histomorphometry at the tibial plateau. Design The local research ethics committee approved the study. All subjects provided written, informed consent. This was a cross-sectional study carried out at our institution between February and August 2014. Ten participants aged 57-84 with knee OA scheduled for total knee arthroplasty (TKA) underwent pre-operative MRI of the symptomatic knee at 3T using a high spatial- resolution coronal T1 weighted sequence. Tibial plateau explants obtained at the time of TKA underwent histological preparation to allow calculation of bone volume fraction (BV.TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) and trabecular number (Tb.N). Texture analysis was performed on the tibial subchondral bone of MRI images matched to the histological sections. Regression models were created to assess the association of texture analysis features with BV.TV, Tb.Th, Tb.Sp and Tb.N. Results MRI texture features were significantly associated with BV.TV (R2 = 0.76), Tb.Th (R2 = 0.47), Tb.Sp (R2 = 0.75) and Tb.N (R2 = 0.60, all p < 0.001). Simple grey-value histogram based texture features demonstrated the highest standardized regression coefficients for each model. Conclusion MRI texture analysis features were significantly associated with ground-truth subchondral bone histomorphometry at the tibial plateau.
dc.description.sponsorshipRoyal College of Radiologists Pump Priming Grant
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.titleSubchondral bone in osteoarthritis: association between MRI texture analysis and histomorphometry.en
dc.typeArticle
prism.endingPage707
prism.publicationDate2017en
prism.publicationNameOsteoarthritis and cartilageen
prism.startingPage700
prism.volume25en
dc.identifier.doi10.17863/CAM.6914
dcterms.dateAccepted2016-12-07en
rioxxterms.versionofrecord10.1016/j.joca.2016.12.011en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-05en
dc.contributor.orcidMacKay, James [0000-0001-7558-3800]
dc.identifier.eissn1522-9653
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (24/15 A)
rioxxterms.freetoread.startdate2017-12-13


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