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dc.contributor.authorPavel, Marianaen
dc.contributor.authorRubinsztein, Daviden
dc.date.accessioned2017-01-05T16:50:06Z
dc.date.available2017-01-05T16:50:06Z
dc.date.issued2017-03en
dc.identifier.issn1742-464X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261752
dc.description.abstractAutophagy (literally "self-eating") is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are degraded. Under stress conditions, such as starvation or oxidative stress, autophagy is upregulated in order to degrade macromolecules and restore the nutrient balance. The source of membranes that participate in the initial formation of phagophores is still incompletely understood and many intracellular structures have been shown to act as lipid donors, including the endoplasmic reticulum, Golgi, nucleus, mitochondria and the plasma membrane. Here we focus on the contributions of the plasma membrane to autophagosome biogenesis governed by ATG16L1 and ATG9A trafficking, and summarise the physiological and pathological implications of this macroautophagy route, from development and stem cell fate to neurodegeneration and cancer. This article is protected by copyright. All rights reserved.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherWiley
dc.subjectCell Membraneen
dc.subjectLysosomesen
dc.subjectMitochondriaen
dc.subjectAnimalsen
dc.subjectMammalsen
dc.subjectHumansen
dc.subjectMembrane Proteinsen
dc.subjectVesicular Transport Proteinsen
dc.subjectEndocytosisen
dc.subjectProtein Transporten
dc.subjectOxidative Stressen
dc.subjectAutophagyen
dc.subjectAutophagy-Related Proteinsen
dc.subjectAutophagosomesen
dc.titleMammalian autophagy and the plasma membrane.en
dc.typeArticle
prism.endingPage679
prism.publicationDate2017en
prism.publicationNameThe FEBS journalen
prism.startingPage672
prism.volume284en
dc.identifier.doi10.17863/CAM.6970
dcterms.dateAccepted2016-10-17en
rioxxterms.versionofrecord10.1111/febs.13931en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-03en
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1742-4658
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095317/Z/11/Z)
pubs.funder-project-idWellcome Trust (095317/Z/11/A)
pubs.funder-project-idEC FP7 MC ITN (264508)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idEC FP7 CP (305121)
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (PF15/DR/9342)
pubs.funder-project-idFederation of the European Biochemical Societies (FEBS) (unknown)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
rioxxterms.freetoread.startdate2017-10-18


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