$\textit{XACT}$ Noncoding RNA Competes with $\textit{XIST}$ in the Control of X Chromosome Activity during Human Early Development
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Peer-reviewed
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Abstract
Sex chromosome dosage compensation is essential in most metazoans, but the developmental timing and underlying mechanisms vary significantly, even among placental mammals. Here we identify human-specific mechanisms regulating X chromosome activity in early embryonic development. Single-cell RNA sequencing and imaging revealed co-activation and accumulation of the long noncoding RNAs (lncRNAs)
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1875-9777
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Medical Research Council (MC_PC_12009)