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dc.contributor.authorBell, Samuelen
dc.contributor.authorTerentjev, Eugeneen
dc.date.accessioned2017-01-10T16:13:05Z
dc.date.available2017-01-10T16:13:05Z
dc.date.issued2016-11-14en
dc.identifier.issn0021-9606
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261803
dc.description.abstractWe examine the population dynamics of naturally folded globular polymers, with a super-hydrophobic "core" inserted at a prescribed point in the polymer chain, unfolding under an application of external force, as in AFM force-clamp spectroscopy. This acts as a crude model for a large class of folded biomolecules with hydrophobic or hydrogen-bonded cores. We find that the introduction of super-hydrophobic units leads to a stochastic variation in the unfolding rate, even when the positions of the added monomers are fixed. This leads to the average non-exponential population dynamics, which is consistent with a variety of experimental data and does not require any intrinsic quenched disorder that was traditionally thought to be at the origin of non-exponential relaxation laws.
dc.description.sponsorshipThis work is supported by the EPSRC through a studentship award and the Critical Mass Grant for Cambridge Theoretical Condensed Matter EP/J017639.
dc.languageengen
dc.language.isoenen
dc.publisherAIP Publishing
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.titleNon-exponential kinetics of unfolding under a constant forceen
dc.typeArticle
prism.issueIdentifier18en
prism.number185102en
prism.publicationDate2016en
prism.publicationNameThe Journal of Chemical Physicsen
prism.volume145en
dc.identifier.doi10.17863/CAM.7020
dcterms.dateAccepted2016-10-20en
rioxxterms.versionofrecord10.1063/1.4966922en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/en
rioxxterms.licenseref.startdate2016-11-14en
dc.contributor.orcidBell, Samuel [0000-0001-5475-4025]
dc.contributor.orcidTerentjev, Eugene [0000-0003-3517-6578]
dc.identifier.eissn1089-7690
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/J017639/1)


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International