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dc.contributor.authorChan, AHen
dc.contributor.authorBoughton, PCen
dc.contributor.authorRuys, AJen
dc.contributor.authorOyen, Michelleen
dc.date.accessioned2017-01-12T10:37:22Z
dc.date.available2017-01-12T10:37:22Z
dc.date.issued2017-01-01en
dc.identifier.issn1751-6161
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261833
dc.description.abstractSevere degeneration of the intervertebral disc has an immensely debilitating effect on quality of life that has become a serious health and economic burden throughout the world. The disc plays an integral role in biomechanical movement and support within the spine. The emergence of tissue engineering endeavours to restore the structural characteristics and functionality of the native tissue. Hydrogels have been widely investigated as a candidate for regeneration of the gelatinous nucleus pulposus due to its architectural resemblance and fluid retention characteristics. However, hydrogels are often limited due to small compressive stiffness and tear resistance, leading to extrusion complications. Reinforcement of the hydrogel network using polymeric scaffolds may address these issues of inadequate mechanical properties and implant instability. This study investigates the potential of a carrageenan gel-infused polycaprolactone scaffold for nucleus pulposus tissue engineering. Mechanical properties were characterised using viscoelastic and poroelastic frameworks via microindentation. The incorporation of polymeric reinforcement within the gels increased material stiffness to that comparable to the native nucleus pulposus, however permeability was significantly greater than native values. A preliminary cell evaluation culturing NIH 3T3s over 21 days suggested the incorporation of polymeric networks also enhanced cellular proliferation compared to gels alone.
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjecthydrogelen
dc.subjectnucleus pulposusen
dc.subjecttissue engineeringen
dc.subjectintervertebraldiscen
dc.subjectcarrageenanen
dc.subjectPCLen
dc.titleAn interpenetrating network composite for a regenerative spinal disc applicationen
dc.typeArticle
prism.endingPage848
prism.publicationDate2017en
prism.publicationNameJournal of the Mechanical Behavior of Biomedical Materialsen
prism.startingPage842
prism.volume65en
dc.identifier.doi10.17863/CAM.7054
dcterms.dateAccepted2016-10-23en
rioxxterms.versionofrecord10.1016/j.jmbbm.2016.10.015en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-01-01en
dc.contributor.orcidOyen, Michelle [0000-0002-3428-748X]
dc.identifier.eissn1878-0180
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-10-26en
rioxxterms.freetoread.startdate2017-10-26


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International