Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease.
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Authors
Usman, Ammara
Sadat, Umar
Boyle, Jonathan R
Varty, Kevin
Publication Date
2017-02Journal Title
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN
1052-3057
Publisher
Elsevier
Volume
26
Pages
347-351
Language
English
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Usman, A., Sadat, U., Teng, Z., Graves, M., Boyle, J. R., Varty, K., Hayes, P., & et al. (2017). Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 26 347-351. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.028
Abstract
$\textit{Background:}$ Functional magnetic resonance (MR) imaging of atheroma using contrast media enables assessment of the systemic severity of atherosclerosis in different arterial beds. Whether black-blood imaging has similar ability remains widely unexplored. In this study, we evaluate whether black-blood imaging can differentiate carotid plaques of patients with and without coronary artery disease (CAD) in terms of morphological and biomechanical features of plaque vulnerability, thereby allowing assessment of the systemic severity nature of atherosclerosis in different arterial beds.
$\textit{Methods:}$ Forty-one patients with CAD and 59 patients without CAD underwent carotid black-blood MR imaging. Plaque components were segmented to identify large lipid core (LC), ruptured fibrous cap (FC), and plaque hemorrhage (PH). These segmented contours of plaque components were used to quantify maximum structural biomechanical stress.
$\textit{Results:}$ Patients with CAD and without CAD had comparable demographics and comorbidities. Both groups had comparable prevalence of morphological features of plaque vulnerability (FC rupture, 44% versus 41%, $P$ = .90; PH, 58% versus 47%, $P$ = .78; large LC, 32% versus 47%, $P$ = .17), respectively. The maximum biomechanical stress was not significantly different for both groups (241versus 278 kPa, $P$ = .14) respectively.
$\textit{Conclusions:}$ Black-blood imaging does not appear to have the ability to differentiate between the morphological and biomechanical features of plaque vulnerability when comparing patients with and without symptomatic atherosclerotic disease in a distant arterial territory such as coronary artery.
Keywords
Brain, Humans, Carotid Artery Diseases, Contrast Media, Magnetic Resonance Imaging, Retrospective Studies, Comorbidity, Aged, Aged, 80 and over, Middle Aged, Female, Male, Coronary Artery Disease, Plaque, Atherosclerotic
Sponsorship
A.U. received funding from Mountbatten Cambridge International Scholarship in collaboration with Cambridge Trust, Christ’s College, and Sir Ernest Cassel Education Trust. U.S. received funding from a Royal College of Surgeons of England/Medical Research Council (United Kingdom) clinical research training fellowship at the time when the study was conducted. This study was supported by NIHR Biomedical Research Centre.
Funder references
TCC (NIHR/CS/009/011)
British Heart Foundation (PG/11/74/29100)
British Heart Foundation (RG/10/007/28300)
EC FP7 CP (224297)
Identifiers
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261923
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