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dc.contributor.authorUsman, Ammaraen
dc.contributor.authorSadat, Umaren
dc.contributor.authorTeng, Zhongzhaoen
dc.contributor.authorGraves, Martinen
dc.contributor.authorBoyle, Jonathan Ren
dc.contributor.authorVarty, Kevinen
dc.contributor.authorHayes, Paulen
dc.contributor.authorGillard, Jonathanen
dc.date.accessioned2017-01-19T11:43:35Z
dc.date.available2017-01-19T11:43:35Z
dc.date.issued2017-02en
dc.identifier.issn1052-3057
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261923
dc.description.abstract$\textit{Background:}$ Functional magnetic resonance (MR) imaging of atheroma using contrast media enables assessment of the systemic severity of atherosclerosis in different arterial beds. Whether black-blood imaging has similar ability remains widely unexplored. In this study, we evaluate whether black-blood imaging can differentiate carotid plaques of patients with and without coronary artery disease (CAD) in terms of morphological and biomechanical features of plaque vulnerability, thereby allowing assessment of the systemic severity nature of atherosclerosis in different arterial beds. $\textit{Methods:}$ Forty-one patients with CAD and 59 patients without CAD underwent carotid black-blood MR imaging. Plaque components were segmented to identify large lipid core (LC), ruptured fibrous cap (FC), and plaque hemorrhage (PH). These segmented contours of plaque components were used to quantify maximum structural biomechanical stress. $\textit{Results:}$ Patients with CAD and without CAD had comparable demographics and comorbidities. Both groups had comparable prevalence of morphological features of plaque vulnerability (FC rupture, 44% versus 41%, $P$ = .90; PH, 58% versus 47%, $P$ = .78; large LC, 32% versus 47%, $P$ = .17), respectively. The maximum biomechanical stress was not significantly different for both groups (241versus 278 kPa, $P$ = .14) respectively. $\textit{Conclusions:}$ Black-blood imaging does not appear to have the ability to differentiate between the morphological and biomechanical features of plaque vulnerability when comparing patients with and without symptomatic atherosclerotic disease in a distant arterial territory such as coronary artery.
dc.description.sponsorshipA.U. received funding from Mountbatten Cambridge International Scholarship in collaboration with Cambridge Trust, Christ’s College, and Sir Ernest Cassel Education Trust. U.S. received funding from a Royal College of Surgeons of England/Medical Research Council (United Kingdom) clinical research training fellowship at the time when the study was conducted. This study was supported by NIHR Biomedical Research Centre.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.subjectBrainen
dc.subjectHumansen
dc.subjectCarotid Artery Diseasesen
dc.subjectContrast Mediaen
dc.subjectMagnetic Resonance Imagingen
dc.subjectRetrospective Studiesen
dc.subjectComorbidityen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectCoronary Artery Diseaseen
dc.subjectPlaque, Atheroscleroticen
dc.titleMagnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease.en
dc.typeArticle
prism.endingPage351
prism.publicationDate2017en
prism.publicationNameJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Associationen
prism.startingPage347
prism.volume26en
dc.identifier.doi10.17863/CAM.7161
dcterms.dateAccepted2016-09-15en
rioxxterms.versionofrecord10.1016/j.jstrokecerebrovasdis.2016.09.028en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-02en
dc.contributor.orcidTeng, Zhongzhao [0000-0003-3973-6157]
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.contributor.orcidHayes, Paul [0000-0002-1968-5930]
dc.contributor.orcidGillard, Jonathan [0000-0003-4787-8091]
dc.identifier.eissn1532-8511
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idTCC (NIHR/CS/009/011)
pubs.funder-project-idBritish Heart Foundation (PG/11/74/29100)
pubs.funder-project-idBritish Heart Foundation (RG/10/007/28300)
pubs.funder-project-idEC FP7 CP (224297)
rioxxterms.freetoread.startdate2017-10-17


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