Single-molecule force spectroscopy quantification of adhesive forces in cucurbituril host-guest ternary complexes.
Del Barrio, J
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Walsh-Korb, Z., Yu, Y., Janecek, E., Lan, Y., Del Barrio, J., Williams, P., Zhang, X., & et al. (2017). Single-molecule force spectroscopy quantification of adhesive forces in cucurbituril host-guest ternary complexes.. Langmuir, 33 (6), 1343-1350. https://doi.org/10.1021/acs.langmuir.6b03457
Cucurbituril (CB) heteroternary complexes display certain characteristics making them well-suited for molecular level adhesives. In particular, the ability to control adhesion through careful choice of host-guest binding pairs enables specific, fully reversible adhesion. Understanding the effect of the environment on the adhesive system is also critical when developing new molecular level adhesives. Here we explore the binding forces involved in the methyl viologen · CB · napthol heteroternary complex using single-molecule force spectroscopy (SMFS) under a variety of conditions. From SMFS, the interaction of a single ternary complex was found to be in the region of 140 pN. Additionally, a number of surface interactions could be readily differentiated using the SMFS technique allowing for a deeper understanding of the dynamic heteroternary CB system on the single-molecule scale.
This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC), the Walters-Kundert Charitable Trust and an ERC Starting Investigator grant (ASPiRe, 240629). ZWK, ERJ, YL thank the Royal Society of Chemistry for a grant allowing travel to Tsinghua University to carry out this research. YY would like to acknowledge financial support from the Young Scientists of the National Science Foundation of China (21304052). YL thanks the Chinese Overseas Scholarship Trust for financial support. JdB thanks the Marie Curie Actions program for financial support. PEW thanks the Atomic Weapons and Energy Commission and the Melville Laboratory for Polymer Synthesis for financial support.
European Research Council (240629)
European Commission (273807)
Royal Society (IE130941)
External DOI: https://doi.org/10.1021/acs.langmuir.6b03457
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261960