Theses - MRC Biostatistics Unit: Recent submissions
Now showing items 1-4 of 23
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Statistical methods to improve understanding of the genetic basis of complex diseases
Robust statistical methods, utilising the vast amounts of genetic data that is now available, are required to resolve the genetic aetiology of complex human diseases including immune-mediated diseases. Essential to this ... -
Approaches to developing clinically useful Bayesian risk prediction models
Prediction of the presence of disease (diagnosis) or an event in the future course of disease (prognosis) becomes increasingly important in the current era of personalised medicine. Both tasks (diagnosis and prognosis) are ... -
Weighting and moment conditions in Bayesian inference
(2021-10-23)The work presented in this thesis was motivated by the goal of developing Bayesian methods for "weighted" biomedical data. To be more specific, we are referring to probability weights, which are used to adjust for ... -
Curtailed phase II binary outcome trials and adaptive multi-outcome trials
(2021-11-27)Phase II clinical trials are a critical aspect of the drug development process. With drug development costs ever increasing, novel designs that can improve the efficiency of phase II trials are extremely valuable. Phase ...
