Assessment of Carotid Plaque Inflammation in Diabetic and Nondiabetic Patients-An Exploratory Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Study.
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Publication Date
2017-04Journal Title
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN
1052-3057
Publisher
Elsevier
Volume
26
Pages
858-862
Language
English
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
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Usman, A., Patterson, A., Sadat, U., Tang, T. Y., Graves, M., & Gillard, J. (2017). Assessment of Carotid Plaque Inflammation in Diabetic and Nondiabetic Patients-An Exploratory Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Study.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 26 858-862. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.10.034
Abstract
$\textit{Background:}$ Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging enables the identification of inflammation within the atheroma, predominantly by USPIO uptake by macrophages present in atherosclerotic tissue. Diabetic patients, however, may have dysfunctional macrophage activity, which may affect utilization of USPIO in identifying plaque inflammation in this patient cohort.
$\textit{Methods:}$ Fifteen diabetic and fifteen nondiabetic patients underwent USPIO-enhanced carotid MR imaging using 1.5T MR system. Pre- and post-USPIO carotid MR images were manually coregistered. The percentage decrease in the signal intensity after USPIO administration was calculated as a relative measure of the USPIO uptake.
$\textit{Results:}$ Diabetic and nondiabetic patients had comparable demographics and comorbidities. The mean global, maximum quadrant, and maximum slice changes showing change in relative signal intensity as a result of USPIO administration were comparable for the two patient cohorts ($\small \textit{P}$ > .05).
$\textit{Conclusions:}$ USPIO can identify inflammatory burden with carotid atheroma in both diabetic and nondiabetic patients.
Keywords
Humans, Carotid Stenosis, Diabetes Mellitus, Inflammation, Dextrans, Magnetic Resonance Imaging, Magnetic Resonance Angiography, Electrocardiography, Statistics, Nonparametric, Image Processing, Computer-Assisted, Aged, Middle Aged, Female, Male, Magnetite Nanoparticles
Sponsorship
AU is funded by Mountbatten Cambridge International Scholarship, in collaboration with Cambridge Trust, Christ’s College, and Sir Ernest Cassel Educational Trust. This study was supported by NIHR Biomedical Research Centre.
Funder references
EC FP7 CP (224297)
British Heart Foundation (RG/10/007/28300)
British Heart Foundation (PG/11/74/29100)
TCC (NIHR/CS/009/011)
Identifiers
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262052
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