Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
Nature Publishing Group
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Rawson, F., Cole, M., Hicks, J., Aylott, J., Milne, W., Collins, C., Jackson, S., et al. (2016). Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes. Scientific Reports, 6 (37672)https://doi.org/10.1038/srep37672
With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct. We show that such a construct is capable of electrochemically communicating with the intracellular environment.
This work was supported by the Leverhulme Trust [grant numbers F/00 094/BD, ECF/2013-603]; the Biotechnology and Biological Sciences Research Council [grant number BB/L017059/1]; the European Research Council [Consolidator Grant, number 614787], the Engineering and Physical Sciences Research Council [EP/K027263/1]; and the NC3Rs [grant number NC/L00058X/1].
NC3Rs (via Plymouth University) (NC/L00058X/1)
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External DOI: https://doi.org/10.1038/srep37672
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262056