Differential regenerative ability of sensory and motor neurons.

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dc.contributor.authorCheah, Menghon
dc.contributor.authorFawcett, James W
dc.contributor.authorHaenzi, Barbara
dc.date.accessioned2017-01-26T15:54:27Z
dc.date.available2017-01-26T15:54:27Z
dc.date.issued2017-06-23
dc.identifier.issn0304-3940
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262069
dc.description.abstractAfter injury, the adult mammalian central nervous system (CNS) lacks long-distance axon regeneration. This review discusses the similarities and differences of sensory and motor neurons, seeking to understand how to achieve functional sensory and motor regeneration. As these two types of neurons respond differently to axotomy, growth environment and treatment, the future challenge will be on how to achieve full recovery in a way that allows regeneration of both types of fibres simultaneously.
dc.description.sponsorshipThis work was supported by grants from the Christopher and Dana Reeve Foundation, the Medical Research Council, the European Research Council ECMneuro, the Cambridge NHMRC Biomedical Research Centre.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.language.isoen
dc.publisherElsevier BV
dc.subjectGrafts
dc.subjectMotor neurons
dc.subjectRegeneration
dc.subjectSensory neurons
dc.subjectSpinal cord
dc.subjectAnimals
dc.subjectAxons
dc.subjectFibroblasts
dc.subjectHumans
dc.subjectMotor Neurons
dc.subjectSensory Receptor Cells
dc.subjectSignal Transduction
dc.subjectSpinal Cord
dc.subjectSpinal Cord Injuries
dc.subjectSpinal Cord Regeneration
dc.subjectTranscription, Genetic
dc.titleDifferential regenerative ability of sensory and motor neurons.
dc.typeArticle
prism.endingPage40
prism.publicationDate2017
prism.publicationNameNeurosci Lett
prism.startingPage35
prism.volume652
dc.identifier.doi10.17863/CAM.7318
dcterms.dateAccepted2016-11-01
rioxxterms.versionofrecord10.1016/j.neulet.2016.11.004
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-06
dc.contributor.orcidCheah, Menghon [0000-0003-1659-3771]
dc.contributor.orcidFawcett, James [0000-0002-7990-4568]
dc.identifier.eissn1872-7972
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R004544/1)
cam.issuedOnline2016-11-03
rioxxterms.freetoread.startdate2017-11-03


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