Differential regenerative ability of sensory and motor neurons.
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Peer-reviewed
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Abstract
After injury, the adult mammalian central nervous system (CNS) lacks long-distance axon regeneration. This review discusses the similarities and differences of sensory and motor neurons, seeking to understand how to achieve functional sensory and motor regeneration. As these two types of neurons respond differently to axotomy, growth environment and treatment, the future challenge will be on how to achieve full recovery in a way that allows regeneration of both types of fibres simultaneously.
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Keywords
Grafts, Motor neurons, Regeneration, Sensory neurons, Spinal cord, Animals, Axons, Fibroblasts, Humans, Motor Neurons, Sensory Receptor Cells, Signal Transduction, Spinal Cord, Spinal Cord Injuries, Spinal Cord Regeneration, Transcription, Genetic
Journal Title
Neurosci Lett
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Journal ISSN
0304-3940
1872-7972
1872-7972
Volume Title
652
Publisher
Elsevier BV
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Sponsorship
Medical Research Council (MR/R004544/1)
This work was supported by grants from the Christopher and Dana Reeve Foundation, the Medical Research Council, the European Research Council ECMneuro, the Cambridge NHMRC Biomedical Research Centre.