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dc.contributor.authorWong, Pen
dc.contributor.authorTan, Ten
dc.contributor.authorChan, Cen
dc.contributor.authorLaxton, Ven
dc.contributor.authorChan, Yinen
dc.contributor.authorLiu, Ten
dc.contributor.authorWong, WTen
dc.contributor.authorTse, Gen
dc.date.accessioned2017-01-27T15:35:40Z
dc.date.available2017-01-27T15:35:40Z
dc.date.issued2016-12-06en
dc.identifier.issn1664-042X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262093
dc.description.abstractGap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They consist of two connexons, with (one) connexon supplied by each cell. A connexon is a hexamer of connexins and currently more than 20 connexin isoforms have been described in the literature thus far. Connexins have a short half-life, and therefore gap junction remodeling constantly occurs with a high turnover rate. Post-translational modification, such as phosphorylation, can modify their channel activities. In this article, the roles of connexins in wound healing and repair are reviewed. Novel strategies for modulating the function or expression of connexins, such as the use of antisense technology, synthetic mimetic peptides and bioactive materials for the treatment of skin wounds, diabetic and pressure ulcers as well as cornea wounds, are considered.
dc.description.sponsorshipGT received a BBSRC Doctoral Training Award at the University of Cambridge and thanks The Croucher Foundation for supporting his clinical assistant professorship. YC is supported by the ESRC for her research at the University of Cambridge.
dc.languageengen
dc.language.isoenen
dc.publisherFrontiers
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectantisense oligodeoxynucleotidesen
dc.subjectconnexin mimetic peptidesen
dc.subjectconnexinsen
dc.subjectgap junction modulatorsen
dc.subjectgap junctionsen
dc.subjectwound healingen
dc.subjectwound repairen
dc.titleThe Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approachesen
dc.typeArticle
prism.number596en
prism.publicationDate2016en
prism.publicationNameFrontiers in Physiologyen
prism.volume7en
dc.identifier.doi10.17863/CAM.7341
dcterms.dateAccepted2016-11-16en
rioxxterms.versionofrecord10.3389/fphys.2016.00596en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-12-06en
dc.identifier.eissn1664-042X
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International