Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review
International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute
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Martínez-Cengotitabengoa, M., Carrascón, L., O'Brien, J., Díaz-Gutiérrez, M., Bermúdez-Ampudia, C., Sanada, K., Arrasate, M., & et al. (2016). Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review. International Journal of Molecular Sciences, 17 (12. 2022)https://doi.org/10.3390/ijms17122022
Depressive disorders appear relatively frequently in older patients, and therefore represent an important disease burden worldwide. Given the high levels of inflammatory parameters found in depressed elderly patients, the "inflammaging" hypothesis is gaining strength. In this systematic review, we summarize current evidence regarding the relationship between inflammatory parameters and late-life depression, with a unique focus on longitudinal studies to guarantee temporality. According to the data summarized in this review, the levels of some proinflammatory parameters-especially interleukin (IL)-8, IL-6, and tumor necrosis factor (TNF)-α-could serve as biomarkers for the future development of depressive symptoms in elderly patients. Proinflammatory cytokines seem to be associated with the future development of clinically significant depression, irrespective of baseline scores, thus indicating that inflammation temporally precedes and increases depression risk. As insufficient research has been conducted in this field, further prospective studies are clearly warranted.
inflammation, aging, depression, late-life
This study was funded by grants from Research Network Center of Mental Health-CIBERSAM (2010-P-02); the Government of Spain “Health Research Fund” FEDER (PI08-1213, PI11-01977, PI14-01900, PI08-0873; PI10-01746; PS09/02002; PI12/02077; PI15-00789; PI13/00451); Ministry of Health and Social Equality (20111064) Policy; Local funding from the Department of Education, Language Policy and Culture of the Basque Government (200911147, 2013111162, 2010111170, SAIO10-PC10BF01); European Comission funds (UE/2012/FI-STAR). We appreciate the support of the University of the Basque Country (GIC10/80, GIC12/84) and the Basque Foundation for Health Innovation and Research-BIOEF. The Psychiatry Research Unit of the University Hospital of Álava-Santiago is supported by the “Stanley Research Foundation” (03-RC-003). John O’Brien is supported by the NIHR Cambridge Biomedical Research Centre awarded to the University of Cambridge, Cambridge University Hospitals NHS Trust and Cambridgeshire and Peterborough NHS Trust.
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
External DOI: https://doi.org/10.3390/ijms17122022
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262431
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