Regulation of IP3 receptors by cyclic AMP.
Published version
Peer-reviewed
Repository URI
Repository DOI
Type
Article
Change log
Authors
Taylor, Colin W
Abstract
Ca2+ and cAMP are ubiquitous intracellular messengers and interactions between them are commonplace. Here the effects of cAMP on inositol 1,4,5-trisphosphate receptors (IP3Rs) are briefly reviewed. All three subtypes of IP3R are phosphorylated by cAMP-dependent protein kinase (PKA). This potentiates IP3-evoked Ca2+ release through IP3R1 and IP3R2, but probably has little effect on IP3R3. In addition, cAMP can directly sensitize all three IP3R subtypes to IP3. The high concentrations of cAMP required for this PKA-independent modulation of IP3Rs is delivered to them within signalling junctions that include type 6 adenylyl cyclase and IP3R2.
Description
Keywords
Ca(2+) stores, Cyclic AMP, IP(3) receptor, Parathyroid hormone, Protein kinase A, Signalling junctions, Animals, Calcium, Calcium Signaling, Cyclic AMP, Gene Expression Regulation, Humans, Inositol 1,4,5-Trisphosphate Receptors
Journal Title
Cell Calcium
Conference Name
Journal ISSN
0143-4160
1532-1991
1532-1991
Volume Title
63
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (101844/Z/13/Z)
Biotechnology and Biological Sciences Research Council (BB/L000075/1)
Biotechnology and Biological Sciences Research Council (BB/L000075/1)
Supported by the Wellcome Trust (101844) and Biotechnology and Biological Sciences Research Council UK (BB/L000075/1).