Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility
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Loss-of-function mutations in the cytosine-5 RNA methylase NSUN2 cause neurodevelopmental disorders in humans, yet the underlying cellular processes leading to the symptoms that include microcephaly remain unclear. Here, we show that NSUN2 is expressed in early neuroepithelial progenitors of the developing human brain, and its expression is gradually reduced during differentiation of human neuroepithelial stem (NES) cells in vitro. In the developing
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2213-6711
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Medical Research Council (MC_PC_12009)
Medical Research Council (MR/M01939X/1)
European Research Council (310360)