Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging
Accepted version
Peer-reviewed
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Abstract
Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.
Description
Keywords
computerised tomography, drugs, medical image processing, porosity, powders, solvation, terahertz wave imaging, TPI, X-ray computed microtomography, dry powder, equivalent volume diameter, hydration, liquid penetration, microstructural changes, pharmaceutical tablets, terahertz pulsed imaging, terahertz reflection measurements, atmospheric measurements, imaging, liquids, microstructure, particle measurements, pharmaceuticals, powders
Journal Title
International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Conference Name
2016 41st International Conference on Infrared, Millimeter, and Terahertz waves (IRMMW-THz)
Journal ISSN
2162-2027
2162-2035
2162-2035
Volume Title
2016-November
Publisher
IEEE
Publisher DOI
Sponsorship
The authors would like to thank the EPSRC for funding.