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dc.contributor.authorThelin, Ericen
dc.contributor.authorCarpenter, Kerien
dc.contributor.authorHutchinson, Peteren
dc.contributor.authorHelmy, Adelen
dc.date.accessioned2017-03-06T09:49:00Z
dc.date.available2017-03-06T09:49:00Z
dc.date.issued2017-03en
dc.identifier.issn1550-7416
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262873
dc.description.abstractInjuries to the central nervous system continue to be vast contributors to morbidity and mortality; specifically, traumatic brain injury (TBI) is the most common cause of death during the first four decades of life. Several modalities are used to monitor patients suffering from TBI in order to prevent detrimental secondary injuries. The microdialysis (MD) technique, introduced during the 1990s, presents the treating physician with a robust monitoring tool for brain chemistry in addition to conventional intracranial pressure monitoring. Nevertheless, some limitations remain, such as limited spatial resolution. Moreover, while there have been several attempts to develop new potential pharmacological therapies in TBI, there are currently no available drugs which have shown clinical efficacy that targets the underlying pathophysiology, despite various trials investigating a plethora of pharmaceuticals. Specifically in the brain, MD is able to demonstrate penetration of the drug through the blood-brain barrier into the brain extracellular space at potential site of action. In addition, the downstream effects of drug action can be monitored directly. In the future, clinical MD, together with other monitoring modalities, can identify specific pathological substrates which require tailored treatment strategies for patients suffering from TBI.
dc.description.sponsorshipThe author(s) gratefully acknowledge receipt of the following financial support. Medical Research Council (Grant nos. G0600986 ID79068 and G1002277 ID98489) and National Institute for Health Research Biomedical Research Centre, Cambridge (Neuroscience Theme; Brain Injury and Repair Theme). Authors’ support: EPT—the Swedish Society of Medicine (Grant no. SLS-587221) and the Swedish Brain Foundation; KLHC—the National Institute for Health Research Biomedical Research Centre, Cambridge (Neuroscience Theme; Brain Injury and Repair Theme); PJH—the National Institute for Health Research Professorship, the Academy of Medical Sciences/Health Foundation Senior Surgical Scientist Fellowship and the National Institute for Health Research Biomedical Research Centre, Cambridge; AH—the Medical Research Council/Royal College of Surgeons of England Clinical Research Training Fellowship (Grant no. G0802251).
dc.languageengen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdrug deliveryen
dc.subjecthumanen
dc.subjectmicrodialysisen
dc.subjectmonitoringen
dc.subjectpharmacokineticsen
dc.subjecttraumatic brain injuryen
dc.titleMicrodialysis Monitoring in Clinical Traumatic Brain Injury and Its Role in Neuroprotective Drug Developmenten
dc.typeArticle
prism.endingPage376
prism.issueIdentifier2en
prism.publicationDate2017en
prism.publicationNameThe AAPS Journalen
prism.startingPage367
prism.volume19en
dc.identifier.doi10.17863/CAM.8164
dcterms.dateAccepted2016-12-07en
rioxxterms.versionofrecord10.1208/s12248-016-0027-7en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-03en
dc.contributor.orcidThelin, Eric [0000-0002-2338-4364]
dc.contributor.orcidCarpenter, Keri [0000-0001-8236-7727]
dc.contributor.orcidHutchinson, Peter [0000-0002-2796-1835]
dc.contributor.orcidHelmy, Adel [0000-0002-0531-0556]
dc.identifier.eissn1550-7416
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0802251)
pubs.funder-project-idMRC (G1002277)
pubs.funder-project-idMRC (G0600986)
cam.issuedOnline2017-01-09en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International