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dc.contributor.authorChewapreecha, Cen
dc.contributor.authorHolden, MTGen
dc.contributor.authorVehkala, Men
dc.contributor.authorVälimäki, Nen
dc.contributor.authorYang, Zen
dc.contributor.authorHarris, SRen
dc.contributor.authorMather, Alisonen
dc.contributor.authorTuanyok, Aen
dc.contributor.authorDe Smet, Ben
dc.contributor.authorLe Hello, Sen
dc.contributor.authorBizet, Cen
dc.contributor.authorMayo, Men
dc.contributor.authorWuthiekanun, Ven
dc.contributor.authorLimmathurotsakul, Den
dc.contributor.authorPhetsouvanh, Ren
dc.contributor.authorSpratt, BGen
dc.contributor.authorCorander, Jen
dc.contributor.authorKeim, Pen
dc.contributor.authorDougan, Gordonen
dc.contributor.authorDance, DABen
dc.contributor.authorCurrie, BJen
dc.contributor.authorParkhill, Julianen
dc.contributor.authorPeacock, Sharonen
dc.date.accessioned2017-03-06T11:20:44Z
dc.date.available2017-03-06T11:20:44Z
dc.date.issued2017-01-23en
dc.identifier.issn2058-5276
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262880
dc.description.abstractThe environmental bacterium $\textit{Burkholderia pseudomallei}$ causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 $\textit{B. pseudomallei}$isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
dc.description.sponsorshipC.C. is a Sir Henry Wellcome post-doctoral Fellow (grant ref: 107376/Z/15/Z). J.C., M.V., Z.Y. were supported by the COIN Centre of Excellence and Z.Y. by a HIIT post-doctoral fellowship. A.E.M. is supported by Biotechnology and Biological Sciences Research Council grant BB/M014088/1. B.G.S. was supported by the Wellcome Trust grant WT089472. D.A.B.D and R.P. are supported by the Wellcome Trust grants 106698/Z/14 and B9R00760. D.L. and V.W. are supported by the Wellcome Trust grant 089275/Z/09/Z. M.M. and B.J.C are supported by the Australian National Health and Medical Research Council through project grants #1046812 and #1098337. This publication presents independent research supported by the Health Innovation Challenge Fund (WT098600, HICF-T5-342), a parallel funding partnership between the Department of Health and Wellcome Trust.
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleGlobal and regional dissemination and evolution of $\textit{Burkholderia pseudomallei}$en
dc.typeArticle
prism.number16263en
prism.publicationDate2017en
prism.publicationNameNature Microbiologyen
prism.volume2en
dc.identifier.doi10.17863/CAM.8171
dcterms.dateAccepted2016-12-08en
rioxxterms.versionofrecord10.1038/nmicrobiol.2016.263en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01-23en
dc.contributor.orcidDougan, Gordon [0000-0003-0022-965X]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidPeacock, Sharon [0000-0002-1718-2782]
dc.identifier.eissn2058-5276
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M014088/1)
pubs.funder-project-idWELLCOME TRUST (107376/Z/15/Z)
cam.issuedOnline2017-01-23en
rioxxterms.freetoread.startdate2017-07-23


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