DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.
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Publication Date
2017-05Journal Title
Nature reviews. Molecular cell biology
ISSN
1471-0072
Publisher
Nature Publishing Group
Volume
18
Pages
279-284
Language
English
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
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Hänsel-Hertsch, R., Di, A. M., & Balasubramanian, S. (2017). DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.. Nature reviews. Molecular cell biology, 18 279-284. https://doi.org/10.1038/nrm.2017.3
Abstract
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.
Keywords
Animals, Humans, Neoplasms, Genomic Instability, DNA, Single-Stranded, Oligonucleotides, DNA Replication, Transcription, Genetic, Gene Expression Regulation, Genome, Human, G-Quadruplexes
Sponsorship
The Balasubramanian laboratory is core-funded by Cancer Research UK (C14303/A17197) and further supported by a Cancer Research UK programme grant (C9681/A18618). S.B. is a Wellcome Trust Senior Investigator (099232/Z/12/Z).
Funder references
Wellcome Trust (099232/Z/12/Z)
Cancer Research UK (18618)
Identifiers
External DOI: https://doi.org/10.1038/nrm.2017.3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262887
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