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dc.contributor.authorWard, HAen
dc.contributor.authorWark, PAen
dc.contributor.authorMuller, DCen
dc.contributor.authorSteffen, Aen
dc.contributor.authorJohansson, Men
dc.contributor.authorNorat, Ten
dc.contributor.authorGunter, MJen
dc.contributor.authorOvervad, Ken
dc.contributor.authorDahm, CCen
dc.contributor.authorHalkjær, Jen
dc.contributor.authorTjønneland, Aen
dc.contributor.authorBoutron-Ruault, M-Cen
dc.contributor.authorFagherazzi, Gen
dc.contributor.authorMesrine, Sen
dc.contributor.authorBrennan, Pen
dc.contributor.authorFreisling, Hen
dc.contributor.authorLi, Ken
dc.contributor.authorKaaks, Ren
dc.contributor.authorTrichopoulou, Aen
dc.contributor.authorLagiou, Pen
dc.contributor.authorPanico, Sen
dc.contributor.authorGrioni, Sen
dc.contributor.authorTumino, Ren
dc.contributor.authorVineis, Pen
dc.contributor.authorPalli, Den
dc.contributor.authorPeeters, PHMen
dc.contributor.authorBueno-de-Mesquita, HBen
dc.contributor.authorWeiderpass, Een
dc.contributor.authorAgudo, Aen
dc.contributor.authorRamon Quiros, Jen
dc.contributor.authorLarrañaga, Nen
dc.contributor.authorArdanaz, Een
dc.contributor.authorHuerta, JMen
dc.contributor.authorSánchez, M-Jen
dc.contributor.authorLaurell, Gen
dc.contributor.authorJohansson, Ien
dc.contributor.authorWestin, Uen
dc.contributor.authorWallstrom, Pen
dc.contributor.authorBradbury, KEen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorPearson, Cen
dc.contributor.authorBoeing, Hen
dc.contributor.authorRiboli, Een
dc.date.accessioned2017-03-07T09:33:12Z
dc.date.available2017-03-07T09:33:12Z
dc.date.issued2017-06en
dc.identifier.issn1055-9965
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262898
dc.description.abstractBACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error. METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m², normal weight (reference): 22.5-24.9 kg/m², overweight 25-29.9 kg/m², obese: > 30 kg/m²], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models. RESULTS: Among men, a BMI < 22.5 kg/m² was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65). CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated. IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.
dc.description.sponsorshipThe coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); ERC- 2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), PI13/00061 to Granada; , PI13/01162 to EPIC-Murcia), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to K.T. Khaw, N.J. Wareham; C570/A16491 to R.C. Travis and C8221/A19170 to Tim Key (EPIC-Oxford), Medical Research Council (1000143 to K.T. Khaw, N.J. Wareham, MR/M012190/1 to Tim Key (EPIC-Oxford)) (United Kingdom).
dc.languageengen
dc.language.isoenen
dc.publisherAmerican Association for Cancer Research
dc.subjecthead and neck cancersen
dc.subjectobesityen
dc.subjectwaist circumferenceen
dc.subjectwaist:hip ratioen
dc.subjectbody mass indexen
dc.subjectsmokingen
dc.titleMeasured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutritionen
dc.typeArticle
prism.endingPage904
prism.issueIdentifier6en
prism.publicationDate2017en
prism.publicationNameCancer Epidemiology, Biomarkers and Preventionen
prism.startingPage895
prism.volume26en
dc.identifier.doi10.17863/CAM.8186
dcterms.dateAccepted2017-01-15en
rioxxterms.versionofrecord10.1158/1055-9965.EPI-16-0886en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-06en
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.identifier.eissn1538-7755
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
cam.issuedOnline2017-02-09en
dc.identifier.urlhttp://cebp.aacrjournals.org/content/26/6/895.article-infoen
rioxxterms.freetoread.startdate2017-08-09


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