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Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides

Published version
Peer-reviewed

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Authors

Williamson, P 
Galván, A 
Gaunt, MJ 

Abstract

A cobalt-catalysed C–H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(II)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology.

Description

Keywords

0399 Other Chemical Sciences

Journal Title

Chemical Science

Conference Name

Journal ISSN

2041-6520
2041-6539

Volume Title

Publisher

Royal Society of Chemistry
Sponsorship
The Royal Society (wm140104)
European Research Council (259711)
Engineering and Physical Sciences Research Council (EP/I00548X/1)
We are grateful to the Herchel Smith Foundation for a scholarship (P. W.) and the Royal Society (Wolfson Merit Award, M. J. G) and the EPSRC (EP/100548X/1) and ERC (ERC-StG-259711) for Fellowships (M. J. G). Mass spectrometry data were acquired at the EPSRC UK National Mass Spectrometry Facility at Swansea University.