Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at $\textit{ADCY7}$
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To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn’s disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences into new and existing genome-wide association study cohorts and tested for association at ~12 million variants in a total of 16,432 cases and 18,843 controls. We discovered a 0.6% frequency missense variant in
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1546-1718
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National Association for Colitis and Crohn's Disease (NACC) (MR/M00533X/1)