Primate embryogenesis predicts the hallmarks of human naïve pluripotency
The Company of Biologists
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Boroviak, T., & Nichols, J. (2017). Primate embryogenesis predicts the hallmarks of human naïve pluripotency. Development, 144 (2), 175-186. https://doi.org/10.1242/dev.145177
Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation embryo and fail to resume development in chimaeric assays. Recent data suggest that human ESCs can be 'reset' to an earlier developmental stage, but their functional capacity remains ill defined. Here, we discuss how the naïve state is inherently linked to preimplantation epiblast identity in the embryo. We hypothesise that distinctive features of primate development provide stringent criteria to evaluate naïve pluripotency in human and other primate cells. Based on our hypothesis, we define 12 key hallmarks of naïve pluripotency, five of which are specific to primates. These hallmarks may serve as a functional framework to assess human naïve ESCs.
Amnion, Epiblast, Extraembryonic, Naïve pluripotency, Postimplantation, Primate
Research in the authors' laboratories is supported by the Wellcome Trust, Medical Research Council (MRC) and Biotechnology and Biological Sciences Research Council, and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute.
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External DOI: https://doi.org/10.1242/dev.145177
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262928
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