This paper outlines a mixed-methods approach to evaluate reconfiguration opportunities for pharmaceutical supply chains (PSCs) arising from a terpene-based renewable chemical feedstock platform technology delivering intermediate products. The proposed approach provides guidance on how to navigate alternative PSC configuration options based on insights into the economic, environmental and social repercussions of each option obtained from both qualitative and quantitative data analyses. A simplified case on manufacturing ‘green’ paracetamol underpinned by real experimental and industry data is used in order to illustrate the pertinence of mixed-methods approaches for integrally mapping alternative PSCs’ configuration options