G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition
Nature Structural and Molecular Biology
Nature Publishing Group
MetadataShow full item record
Sahakyan, A., Murat, P., Mayer, C., & Balasubramanian, S. (2017). G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition. Nature Structural and Molecular Biology, 24 (3), 243-247. https://doi.org/10.1038/nsmb.3367
Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3' untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.
S.B. is a Wellcome Trust Senior Investigator (grant 099232/z/12/z). The Balasubramanian group is supported by European Research Council Advanced Grant 339778, and receives core (C14303/A17197) and program (C9681/A18618) funding from Cancer Research UK.
Wellcome Trust (099232/Z/12/Z)
European Research Council (339778)
Cancer Research UK (18618)
External DOI: https://doi.org/10.1038/nsmb.3367
This record's URL: https://www.repository.cam.ac.uk/handle/1810/263082