Inflammation and infection in human cocaine addiction
Current Opinion in Behavioral Sciences
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Ersche, K., & Döffinger, R. (2017). Inflammation and infection in human cocaine addiction. Current Opinion in Behavioral Sciences, 13 203-209. https://doi.org/10.1016/j.cobeha.2016.12.007
Over the past 30 years, the effects of cocaine on the immune system have been subject to research mainly in animals, while relatively little work has been done in humans. This review focuses exclusively on the human work and the related findings in a way that is accessible to neuroscientists. The emerging picture suggests that cocaine may exert some direct effects on lymphocyte responses, as well as, and possibly more importantly, indirect effects via interactions with the sympathetic and neuroendocrine systems. Given the pressing need for more effective treatments for cocaine addiction and the high prevalence of medical complications associated with this disorder, this review leaves no doubt that drug addiction merits a place in the growing field of neuropsychoimmunology.
Our work described in this article was funded by the NIHR Cambridge Biomedical Research Centre.
External DOI: https://doi.org/10.1016/j.cobeha.2016.12.007
This record's URL: https://www.repository.cam.ac.uk/handle/1810/263096