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Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice

Published version
Peer-reviewed

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Authors

Evans, KA 
Andreopoulou, E 
Dimitriou, C 
Koutsakis, C 

Abstract

wo populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche. pOPCs are committed perinatally and retain their numbers through self-renewing divisions, while SEZ-derived cells are relatively “young,” being constantly born from neural stem cells. We compared the behavior of these populations, labeling SEZ-derived cells using hGFAP:CreErt2 mice, within the homeostatic and regenerating CC of the young-adult and aging brain. We found that SEZ-derived oligodendroglial progenitors have limited self-renewing potential and are therefore not bona fide OPCs but rather “oligodendroblasts” more similar to the neuroblasts of the neurogenic output of the SEZ. In the aged CC their mitotic activity is much reduced, although they still act as a “fast-response element” to focal demyelination. In contrast to pOPCs, they fail to generate mature myelinating oligodendrocytes at all ages studied.

Description

Keywords

oligodendrocyte progenitor cell, oligodendroblast, OPC, subependymal zone, subventricular zone, myelin, myelination, corpus callosum, ageing, neural stem cell, demyelination, remyelination

Journal Title

Stem Cell Reports

Conference Name

Journal ISSN

2213-6711
2213-6711

Volume Title

8

Publisher

Elsevier (Cell Press)
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/I013210/1)
Medical Research Council (MC_PC_12009)
This work was supported by a grant from the Biotechnology and Biological Sciences Research Council (UK) ( BB/I013210/1 ) to R.F. and I.K.