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dc.contributor.authorOsei-Amponsah, Ren
dc.contributor.authorSkinner, Benjaminen
dc.contributor.authorAdjei, DOen
dc.contributor.authorBauer, Jen
dc.contributor.authorLarson, Gen
dc.contributor.authorAffara, Nabeelen
dc.contributor.authorSargent, Caroleen
dc.date.accessioned2017-03-27T10:50:34Z
dc.date.available2017-03-27T10:50:34Z
dc.date.issued2017-02-20en
dc.identifier.issn1471-2164
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/263252
dc.description.abstractBACKGROUND: The Ashanti Dwarf Pig (ADP) of Ghana is an endangered pig breed with hardy and disease resistant traits. Characterisation of animal genetic resources provides relevant data for their conservation and sustainable use for food security and economic development. We investigated the origin and phylogenetic status of the local ADP of Ghana and their crosses with modern commercial breeds based on mtDNA, MC1R, Y-chromosome sequence polymorphisms, and genome-wide SNP genotyping. RESULTS: The study involved 164 local pigs sampled from the three agro-ecological zones of Ghana. Analyses of the mitochondrial D-loop region and Y-chromosome sequences revealed both European and Asian genetic signatures, with differences between the geographical zones. Black coat colour is the most predominant within the breed, with black MC1R alleles of both Asian and European origin. European alleles for spotting are present at a low frequency in the sample set, and may account for the occurrence of spotted piglets in some APD litters. PCA analysis of SNP data revealed a strong location and breed effect on clustering of local Ghanaian pigs. On a global level, Ghanaian local pigs cluster closely with European pigs of commercial origin, but we identified intervals via FST analyses that may elucidate loci for ADP specific traits. CONCLUSIONS: The presence of both European and Asian contributions, with differences between geographical zones probably reflects trading and colonial influences. Understanding the effects of admixture on important adaptive and economic traits of the ADP and other local breeds in Africa is critical for developing sustainable conservation programmes to prevent the decline of these genetic resources.
dc.description.sponsorshipThe authors are grateful to Cambridge in Africa Research Excellence (CAPREx) for the award of Post-doctoral Fellowship to ROA, and the Alborada Trust for supporting the Research. G.L is supported by the European Research Council (337574-UNDEAD), and BMS is supported by BBSRC grant number BB/N000129/1. CAS is funded by the Department of Pathology and Hughes Hall, Cambridge.
dc.languageengen
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectD-Loopen
dc.subjectgene sequencingen
dc.subjectlocal pigsen
dc.subjectSNP genotypingen
dc.titleOrigin and phylogenetic status of the local Ashanti Dwarf pig (ADP) of Ghana based on genetic analysis.en
dc.typeArticle
prism.issueIdentifier1en
prism.number193en
prism.publicationDate2017en
prism.publicationNameBMC Genomicsen
prism.volume18en
dc.identifier.doi10.17863/CAM.8572
dcterms.dateAccepted2017-02-02en
rioxxterms.versionofrecord10.1186/s12864-017-3536-6en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-02-20en
dc.contributor.orcidSkinner, Benjamin [0000-0002-7152-1167]
dc.contributor.orcidSargent, Carole [0000-0002-4205-3085]
dc.identifier.eissn1471-2164
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/N000129/1)
cam.orpheus.successThu Jan 30 12:56:34 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International