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dc.contributor.authorMenzies, FMen
dc.contributor.authorFleming, Angeleenen
dc.contributor.authorCaricasole, Aen
dc.contributor.authorBento, CFen
dc.contributor.authorAndrews, Stephenen
dc.contributor.authorAshkenazi, Aen
dc.contributor.authorFüllgrabe, Jen
dc.contributor.authorJackson, Aen
dc.contributor.authorJimenez Sanchez, Men
dc.contributor.authorKarabiyik, Cansuen
dc.contributor.authorLicitra, Florianaen
dc.contributor.authorLopez Ramirez, Anaen
dc.contributor.authorPavel, Men
dc.contributor.authorPuri, Claudiaen
dc.contributor.authorRenna, Maurizioen
dc.contributor.authorRicketts, Ten
dc.contributor.authorSchlotawa, Len
dc.contributor.authorVicinanza, Mariellaen
dc.contributor.authorWon, Hen
dc.contributor.authorZhu, Yen
dc.contributor.authorSkidmore, Johnen
dc.contributor.authorRubinsztein, Daviden
dc.date.accessioned2017-04-06T16:25:33Z
dc.date.available2017-04-06T16:25:33Z
dc.date.issued2017-03-08en
dc.identifier.issn0896-6273
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/263493
dc.description.abstractAutophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with intracytoplasmic aggregate-prone protein accumulation as well as other roles, including in neuronal stem cell differentiation. We then describe how autophagy may be affected in a range of neurodegenerative diseases. Finally, we describe how autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions and consider possible pathways and druggable targets that may be suitable for this objective.
dc.description.sponsorshipD.C.R. is grateful for funding from the Tau Consortium, Alzheimer’s Research UK, Wellcome Trust (Principal Research Fellowship 095317/Z/11/Z), a Wellcome Trust Strategic Grant to the Cambridge Institute for Medical Research (100140/Z/12/Z), NIHR Biomedical Research Unit in Dementia at Addenbrooke’s Hospital, The Rosetrees Trust, FEBS (long-term fellowships to A.A. and J.F.), Addenbrooke’s Charitable Trust, Sims Scholarship, and the James Baird Fund (R.F.). F.M.M. is currently an employee of Eli Lilly and Co.
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectautophagyen
dc.subjectlysosomeen
dc.subjectneurodegenerationen
dc.subjectAlzheimer’s diseaseen
dc.subjectHuntington’s diseaseen
dc.subjectParkinson’s diseaseen
dc.subjectdementiaen
dc.subjectmotor neuron diseaseen
dc.subjecttauen
dc.titleAutophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunitiesen
dc.typeArticle
prism.endingPage1034
prism.issueIdentifier5en
prism.publicationDate2017en
prism.publicationNameNeuronen
prism.startingPage1015
prism.volume93en
dc.identifier.doi10.17863/CAM.8840
dcterms.dateAccepted2017-01-24en
rioxxterms.versionofrecord10.1016/j.neuron.2017.01.022en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-03-08en
dc.contributor.orcidFleming, Angeleen [0000-0003-3721-7126]
dc.contributor.orcidSkidmore, John [0000-0001-9108-7858]
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1097-4199
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (095317/Z/11/Z)
rioxxterms.freetoread.startdate2018-03-08


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International